Research Biologist GS-0401-13

Vacancy ID: 829890   Announcement Number: HHS-FDA-CFSN-DE-13-829890   USAJOBS Control Number: 336189000

Occupational/Assessment Questions:

1. From the descriptions below, please choose the BEST answer that demonstrates that you meet the education and/or experience requirements for the GS-401-13 Research Biologist position.

A. I possess a four-year degree in biological sciences, agriculture, natural resource management, chemistry, or related disciplines appropriate to the position.
B. I have a combination of education and experience: Courses equivalent to a major, as shown in above, plus appropriate experience or additional education.
C. My education and/or experience is not reflected in the choices above.

2. From the descriptions below, please choose the BEST answer that demonstrates that you meet the specialized experience requirements for the GS-401-13 Research Biologist position.

A. I have one year of specialized experience equivalent to the GS-12 in the Federal service that included developing, evaluating, and conducting research activities using in vitro and in vivo methodology to assess toxicity and working on project teams collaborating with other scientist and professional staff members on toxicity issues.
B. My experience is not reflected in the choice above.

For each task in the following group, choose the statement from the list below that best describes your experience and/or training. Darken the oval corresponding to that statement in Section 25 of the Qualifications and Availability Form C. Please select only one letter for each item.

A- I have not had education, training or experience in performing this task.
B- I have had education or training in performing the task, but have not yet performed it on the job.
C- I have performed this task on the job. My work on this task was monitored closely by a supervisor or senior employee to ensure compliance with proper procedures.
D- I have performed this task as a regular part of a job. I have performed it independently and normally without review by a supervisor or senior employee.
E- I am considered an expert in performing this task. I have supervised performance of this task or am normally the person who is consulted by other workers to assist them in doing this task because of my expertise.

3. Screen for toxicity of components found in the food supply.

4. Consult and remain current with in vitro and ex vivo literature especially in methods for evaluation of liver and kidney toxicology.

5. Develop and/or identify methods/biomarkers for screening for liver and renal toxicity of dietary supplements and botanicals.

6. Address difficult research problems in in vitro screening for liver and kidney toxicity, such as identification of appropriate cell types (human and rodent) and biomarkers for identifying and evaluating mechanisms of liver and renal toxicity.

7. Conduct research under Biosafety Level 2 level conditions using human, rodent cell cultures, tissues, biofluids, and extracts.

8. Discuss methodical problems and possible solutions with team leader and supervisor.

9. Interpret significance of research data.

10. Present results to other scientists at symposia, workshops, and national meetings.

11. Develop and coordinate research experimentation/collaboration with other research laboratories.

12. Share information and mentor others in performance of in in vitro cell culture methods and biomarkers.

13. Interact with others within a laboratory unit/division by sharing experimental p protocols, standard operating procedures, and data.

14. Prepare written reports that are of quality that can be used for publications and presentations.

15. Articulate the basis and rational experimental approaches activities in internal written reports.

16. Maintain reports of experimental results via electronically and written notebooks methods.

17. Maintain interdisciplinary expertise in in vitro methods, assays, models, instrumentation and biomarkers of liver and kidney toxicity.

18. Maintain cell culture lines.

19. Prepare cell and tissue homogenates and extracts.

20. Perform assays such as cell viability, reactive oxygen species, cytochrome P450 assays, changes in neutral and phospholipid changes in mitochondrial membranes potential, oxidative stress, and proteome profiling arrays.

21. Operate instrumentation including spectroflorometric and luminescence plate reader.

22. Utilize flow cytometer (GUAVA) for experiences.

23. Operate instrumentation including bead and laser based (BioPlex) assays.